ALZHEIMER ALARMS

ALZHEIMER DISEASE ,WITH A GENETIC ETIOLOGY IN 80 PER CENT OF
CASES.GENE VARIANTS OF ALZHEIMER'S ARE:
APO E4.ALSO TWO MORE VARIANTS AGAINST BRAIN RESTRAINING INFLAMMATION,AS CAUSE OF DISEASE.
 ENVIRONMENTAL FACTORS,INTERFERES WITH INTELLECTUAL ALERTNESS AND MENTAL ACTIVITIES,CAUSING DEMENTIA.ACCORDING TO "DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,AUG 2009,A HIGH RATE OF BLOOD CHOLESTEROL IN MIDDLE AGE CAN INCREASE THE RISK OF ALZHEIMER'S AND DEMENTIA IN OLDER AGES IT IS DIAGNOSED PATHOLOGICALLY IN THE BRAIN BY:
-PLAQUES
-TANGLES OF NEUROFIBRILLS
-DEATH OF NEURONS OR NERVE CELLS
CLINICAL DIAGNOSIS OF ALZHEIMER DISEASE IS BASED ON:
-AMNESIA AND LACK OF COGNITION
-DIFFICULTY IN RECOGNIZING
-DEPRESSION,ADDING TO PHYSICAL SIGNS
-CONFUSION
-PSYCHOSIS
-PARANOIA AND CHANGES IN PERSONALITY
-DIFFICULTY IN JUDGEMENT
-IN ALZHEIMER ,MEMORY IS GRADUALLY LOST.
LOSS OF CELLS AT THE LEVEL OF CORTEX AND BASAL FOREBRAIN IS COMMONESPECIALLY WITH ACETHYLCHOLINE NEUROTRANSMITTER NEURONS AND THE TARGET NERVE CELLS.RECENT STUDIES SHOW THAT EVEN WITH THESE PATHOLOGICAL FINDINGS IN THE BRAIN.INDIVIDUALS WHO ARE ACTIVE INTELLECTULALLY(AND PHYSICALLY,AS WELL) AND HAD A BETTER EDUCATION AND OR VERBAL SKILLS IN EARLY LIFE,CAN DELAY THE ONSET OF ALZHEIMER'S DISEASE.
STROGEN AND TESTOSTERON CAN BE EFFECTIVE IN PREVENTION
TACRINE(COGNEX)10 MG IN A DAY IS BEING USED FOR TX BUT IT MAY CAUSE NAUSEA AND VOMITING AND INCREASES THE LEVEL OF LIVER ENZYMES(LIVER TOXICITY)BUT THIS IS A TEMPORARY SIDE EFFECT AND RETURN OF COGNITION IS SEEN WITHIN 6 MONTHS.
ZOLOFT CAN BE HELPFUL IN TX OF DEPRESSION AND CAN BE USED ADDITIONALLY.
ANTIOXIDANTS ARE LOWERING FREE RADICALS IN BLLOD WHICH ARE DAMAGING CELLS AND NEURONS ,BUT WITH USE OF ANTIOXIDANTS THERE IS LESS CHANCE OF ALZHEIMER'S DISEASE.
ACCORDING TO NATIONAL ACADEMY OF SCIENCE,IN ADULTS WHO HAVE MENTAL HUBBIES SUCH AS READING BOOKS AND MAGAZINES,PLAYING CHESS AND PUZZLES THERE ARE 2.5 PER CENT LESS CHANCE OF THIS DISEASE.ALSO UNSATURATED FATS OF VEGETABLES,
HAVE THE SAME BENEFICIAL EFFECTS,WHILE SATURATED FATS IN RED MEATS,CHICKENS AND DAIRY PRODUCTS INCREASES CHANCE OF ALZHEIMER'S TO 2.3 PER CENT(arch.neuro,2/2003).VITAMINES C AND E WAS NOT A PREVENTIVE FACTOR(SAME REF.)
SEE:
J.C.TRONCOSO,S ARTICLE IN JOURNAL OF NEUROLOGY,JULY2009
ARCHIVE GEN PSYCHIATRY,2/06
-F.S.
UPDATE: 9/29/'09